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Conventional oral solid dosage forms like tablets and capsules in spite of their several advantages and resultant popularity suffer from one great disadvantage, i.e., they have to be swallowed preferably with water or any other liquid. Voluntary swallowing is a hindrance in drug administration for children, elderly, mentally challenged, nauseated, unconscious and bed ridden patients. A need for non-obstructive dosage form possessing the other advantages of tablet has been felt constantly by the physicians and patients for many years. The concept of Oral Thin Films as drug delivering dosage forms evolved from this need of a large group of patient
Our Patented Thinoral technology for manufacturing Thin Films yields instantly wettable, rapidly dissolving, non-sticky, non-tacky and non-curving films with drug loading, as high as 100 mg of the active drug. These films, when placed on the tongue, get wetted by saliva, adhere to the tongue mucosa and disintegrate almost instantaneously. The fast dissolving feature of the film is appreciated by consumers and physicians alike.
Uniform thinness provides large surface area while mechanical foldability renders it almost free from transit breakage. The fast dissolution of the films additionally helps to obtain faster release profiles that help to alleviate solubility issues of many poorly soluble drugs. Thinoral technology is especially suitable for the delivery of thermolabile drugs thus widening the range of drug molecules that can be delivered via thinorals.
This thin film manufacturing technology has in exceptional cases been further advanced for the delivery of even liquid actives, hence expanding the horizons for delivery of drug molecules with Thinoral technology platform. A unique feature of this process is that it allows successful incorporation of many taste masking techniques to facilitate easy delivery of bitter actives. Unlike orally disintegrating tablets that are manufactured using lyophilisation or low compression pressure, the Thinoral films areflexible and offer ease of storage and transportation.
The technology is also suitable for the delivery of drugs through sublingual and buccal route, showing improved bioavailability by avoiding first pass metabolism. Even nanotechnology based formulations have been designed using the Thinoral technology platform that retains all the desired product attributes.
Compared to other Oral Film manufacturing technologies,Thinoral technology uniquely uses robust and cost effective high-throughput manufacturing processes allowing for enhanced stability, content uniformity, acceptable taste and dissolution for a large number of drug candidates.;
Overall, Thinoral technology, offers successful delivery of drug molecules with varying characteristics and critical limitations to special patient groups simultaneously providing a once in life-time opportunity to create new or extend existing brands for the marketing team with a unique new dosage form possessing a high technology barrier for competition!
Thinoral technology has unique features that make the job of healthcare provider easy by providing a very convenient option of medication.
Thinorals have brought a revolution in the concept of drug administration because of the number of advantages offered including
|ORALLY DISINTEGRATING STRIPS (Orodispersible Film)|
|SN||GENERIC NAME||STRENGTH (mg)||THERAPEUTIC USE||PACK PRESENTATION|
|1||Ondansetron (Hydrochloride)||4 / 8||Anti-Emetic||10 X 1 AAP|
|2||Tadalafil||5 / 10 / 20||Benign Prostatic hyperplasia, Erectile Dysfunction||10 X 1 AAP|
|3||Sildenafil (Citrate )||25 / 50||Erectile Dysfunction||10 X 1 AAP|
|4||Methylcobalamin||1500 mcg||Vitamin B12 supplement||10 X 1 AAP|
|5||Levocetirizine Dihydrochloride||5||Anti-Allergic / Nasal Decongestant||10 X 1 AAP|
|6||Montelukast (Sodium)||10||Anti-Asthmatic / Anti-Allergic||10 X 1 AAP|
|7||Vitamin D3||2000 IU||Vitamin D3 supplement||10 X 1 AAP|
|8||Menthol Mouth freshener||...||Mouth Freshener (Mint Flavour) & Others||30 strips/films per cassette|
|1||Ondansetron (Hydrochloride)||2||Anti-Emetic||10 X 1 AAP|
|2||Tadalafil||2.5||Benign Prostatic hyperplasia, Erectile Dysfunction||10 X 1 AAP|
|3||Melatonin||0.5 / 1 / 3 / 5||Sedatives & Hypnotics||10 X 1 AAP|
|4||Folic Acid||0.5||Vitamins & Minerals||10 X 1 AAP|
|5||Simethicone||62.5||Anti- Flatulent||10 X 1 AAP|
|6||Levocetirizine Dihydrochloride||2.5||Anti-Allergic / Nasal Decongestant||10 X 1 AAP|
|7||Montelukast (Sodium)||4 / 5||Anti-Asthmatic/ Anti-Allergic||10 X 1 AAP|
|8||Rizatriptan Benzoate||5/ 10||Anti-Migraine||10 X 1 AAP|
|9||Voglibose||0.2/ 0.3||Anti- Diabetic||10 X 1 AAP|
|10||Zolmitriptan||2.5 / 5||Anti-Migraine||10 X 1 AAP|
|11||Nicotin (Resinate)||2 / 4||Cholinergic Drugs||10 X 1 AAP|
Abbreviation: AAP = Alu - Alu Pouch
|SN||GENERIC NAME||STRENGTH (mg)||THERAPEUTIC USE|
|Orally Disintegrating Strips (Orodispersible Film)|
|1||Donepezil Hydrochloride||5 / 10||Choline - Esterase Inhibitors. (Neuro - Degenerative drugs)|
|2||Olanzapine||2.5/ 5/ 7.5/ 10/ 15/ 20||Anti-psychotic|
|3||Haloperidol||0.5/ 1/ 1.5/ 2 / 5 / 10||Anti-psychotic & Anti-Emetics|
|5||Loperamide Hydrochloride||2 / 5||Anti-Diarrheal|
|6||Clonazepam||0.5 / 1 / 2||Anxiolytics & Anti-Epileptics|
|1||Buprenorphine (HCl) + Naloxone (HCl)||2+0.5/ 4+1/ 8+2/ 12+3||Opiods Analgesics|
|2||Fentanyl citrate||200/400/600/800/1200 mcg||Opiods Analgesics|
|3||Teriparatide||20/ 250/ 600 / 750 mcg||Arthritis/ Osteoporosis|
|1||Vitamin D3||200 / 400 / 600 / 800 / 1000 IU||Vitamin D3 Supplement|
|2||Methylcobalamin||250 / 500 / 1000 mcg||Vitamin B12 Supplement|
|3||Zingiber Officinale (Ginger)||Sore throat, travel sickness, nausea & indigestion|
|4||Baccopa Monnieri (Bramhi)||100||Tranquilizer, Antioxidant, Adaptogen|
|5||Bacillus Coagulence (Lactobacillus Sporogen)||150 msg||For the treatment of Irritable bowel syndrome & for diarrhea (viral, traveler & antibiotics induceddiarrhea)|
|6||Withania Somnifera (Ashwagandha)||100||Adaptogen|
|7||Niacin (Vitamin B3)||75||Vitamins & Minerals|